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ETS translocation variant 3; ETS domain transcriptional repressor PE1; PE-1; mitogenic Ets transcriptional suppressor (ETV3, METS, PE1)
Function:
- transcriptional repressor
- contributes to growth arrest during terminal macrophage differentiation by repressing target genes involved in Ras-dependent proliferation
- represses MMP1 promoter activity
Structure:
- belongs to the ETS family
- contains 1 ETS DNA-binding domain
Compartment: nucleus (putative)
Alternative splicing: named isoforms=2
General
Ets family protein
Properties
SIZE: entity length = 512 aa
MW = 57 kD
COMPARTMENT: cell nucleus
MOTIF: ETS domain
NAME: ETS domain
SITE: 35-116
Database Correlations
OMIM 164873
UniProt P41162
Pfam PF00178
Entrez Gene 2117
Kegg hsa:2117
References
UniProt :accession P41162