ETS-related transcription factor Elf-4 (E74-like factor 4, myeloid Elf-1-like factor, ELF4, ELFR, MEF)

Function: - transcriptional activator - binds to DNA sequencescontaining the consensus 5'-WGGA-3' - transactivates promoters of hematopoietic growth factor genes CSF2, IL3, IL8, & of bovine lysozyme gene - acts synergistically with RUNX1 to transactivate IL3 promoter - transactivates PRF1 promoter in natural killer cells - role in development & function of NK & NK T-cells & in innate immunity - interacts via an N-terminal region with RUNX1 Runt domain - interacts via its C-terminus with PML; interaction enhances ELF4 transactivation of bovine lysozyme gene Structure: - belongs to the ETS family - contains 1 ETS DNA-binding domain Compartment: - nucleus - accumulation into PML nuclear bodies is mediated by PML Expression: - expressed in the placenta > heart, lung, spleen, thymus, peripheral blood lymphocytes, ovary, colon > Jurkat T-cells & other T-cell lines - no expression in brain Pathology: - expressed in a variety of myeloid leukemia cell lines - induced by ponisterone A in erythroleukemia cells

General

DNA-binding protein ETS-related transcription factor Elf

Properties

SIZE: MW = 71 kD entity length = 663 aa COMPARTMENT: cell nucleus MOTIF: binding site SITE: 87-206 FOR-BINDING-OF: CBF-alpha 2 ETS domain NAME: ETS domain SITE: 209-291

Database Correlations

UniProt Q99607 Pfam PF00178

References

UniProt :accession Q99607