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ETS-related transcription factor Elf-2; E74-like factor 2; new ETS-related factor (ELF2, NERF)
Function:
1) isoform 1 transcriptionally activates LYN & BLK promoters
- acts synergistically with RUNX1 to transactivate BLK promoter
2) isoform 2 transcriptional repression of RUNX1 (putative)
3) interacts with LIM domains of LMO2
4) interacts with RUNX1
Compartment:
- nucleus
Alternative splicing:
- named isoforms=5
Expression:
- expressed ubiquitously in fetal & adult tissues
- in fetal tissues, expression in heart, lung, liver, kidney > brain
- in adult tissues, expression in heart, placenta, lung, skeletal muscle, spleen, thymus, testis, ovary > prostate, small intestine, kidney, liver, pancreas > colon, brain, peripheral blood lymphocytes
General
DNA-binding protein
ETS-related transcription factor Elf
phosphoprotein
Properties
SIZE: MW = 64 kD
entity length = 593 aa
COMPARTMENT: cell nucleus
MOTIF: Ser phosphorylation site {S191}
DNA-binding motif
SITE: 208-290
Database Correlations
UniProt Q15723
Pfam PF00178
References
UniProt :accession Q15723