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protein CBFA2T1; protein MTG8; protein ETO; Eight twenty one protein; cyclin-D-related protein; zinc finger MYND domain-containing protein 2 (RUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2)
Function:
- transcription factor (putative)
- binds to histone deacetylases & transcription factors
- can repress transactivation mediated by TCF12 homotetramer, & heterotetramer with CBFA2T2 & CBFA2T3
- interacts with TCF12, SIN3A, HDAC1, HDAC2, HDAC3, NCOR1 & NCOR2
Structure:
- the TAFH domain mediates interaction with transcription regulators
- belongs to the CBFA2T family
- contains 1 MYND-type Zn+2 finger
- contains 1 TAFH (NHR1) domain
Compartment: nucleus (putative)
Alternative splicing: named isoforms=2
Expression:
- expressed in brain > lung, heart, testis, ovary
Pathology:
- chromosomal translocation t(8;21)(q22;q22) involving ETO with RUNX1/AML1 is a cause of acute myeloid leukemia (AML-M2)
- defects in RUNX1T1 may be a cause of colorectal adenocarcinoma
Related
eto gene
General
nuclear protein
phosphoprotein
zinc finger protein
Properties
SIZE: entity length = 604 aa
MW = 68 kD
COMPARTMENT: cell nucleus
MOTIF: breakpoint {30-31}
proline-rich region
SITE: 57-60
MOTIF: proline residue (SEVERAL)
serine-rich region {102-108}
MOTIF: serine residue (SEVERAL)
TAFH {120-215}
proline-rich region
SITE: 290-297
MOTIF: proline residue (SEVERAL)
Important for oligomerization {337-383}
serine-rich region {408-413}
MOTIF: serine residue (SEVERAL)
Zinc finger
NAME: Zinc finger
SITE: 515-551
EFFECTOR-BOUND: Zn+2
Thr phosphorylation site {T592}
Thr phosphorylation site {T595}
Database Correlations
OMIM correlations
UniProt Q06455
PFAM correlations
Entrez Gene 862
Kegg hsa:862
References
- UniProt :accession Q06455
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/ETO.html