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ethotoin; 3-ethyl-5-phenyl-2,4-imidazolidinedione (Peganone)
Indications:
- treatment of epilepsy (not widely used)
- grand mal seizures
- complex partial seizures
Dosage:
- start 250 mg PO QID
- usual adult maintenace dose: 2-3 grams/day divided in 4-6 doses per day
- < 2 g/day generally ineffective in adults
Tablets: 250 mg
Adverse effects:
- less gingival hyperplasia & hirsutism than phenytoin
- lymphadenopathy
- systemic lupus erythematosus
- ataxia
- gum hypertrophy
- nausea, vomiting or nausea
- other:
- chest pain, nystagmus, diplopia, fever, dizziness, diarrhea, headache, insomnia, fatigue, numbness, skin rash, Stevens-Johnson syndrome
Mechanism of action:
- less effective than phenytoin
Interactions
drug interactions
drug adverse effects of anticonvulsants
monitor with anticonvulsants
General
anticonvulsant
References
- Wikipedia: Ethotoin
http://en.wikipedia.org/wiki/Ethotoin
- RxList
http://www.rxlist.com/peganone-drug.htm