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ESCRT-1 complex; endosomal sorting complex required for transport 1
Function:
- regulator of vesicular trafficking
Structure:
- subunits: TSG101, VPS28, a VPS37 protein (VPS37A, VPS37B, VPS37C, VPS37D) & MVB12A or MVB12B in a 1:1:1:1 stoechiometry
General
molecular complex
Properties
SUBUNITS: vacuolar protein sorting-associated protein 28
vacuolar protein sorting-associated protein 37D
MOTIF: VPS37 C-terminal {93-182}
tumor susceptibility gene 101 protein
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: UEV {1-133}
coiled coil {235-316}
PTAP {320-323}
SB {346-390}
vacuolar protein sorting-associated protein 37D
MOTIF: VPS37 C-terminal {93-182}
multivesicular body subunit 12A
COMPARTMENT: cytoplasm
cell nucleus
MOTIF: MABP {9-151}
MOTIF: Thr phosphorylation site {T130}
SH3-binding site
NAME: SH3-binding site
SITE: 155-160
Ser phosphorylation site {S163}
Ser phosphorylation site {S170}
TSG101/VPS37B /VPS28 interaction {192-273}
MOTIF: Ser phosphorylation site {S202}
Tyr phosphorylation site {Y204}
Ser phosphorylation site {S207}
UMA {215-265}
Ser phosphorylation site {S232}
multivesicular body subunit 12B
References
- UniProt :accession Q8IY31
- UniProt :accession Q96EY5
Components
multivesicular body subunit 12A; CIN85/CD2AP family-binding protein; ESCRT-I complex subunit MVB12A; protein FAM125A (MVB12A, CFBP, FAM125A)
multivesicular body subunit 12B; ESCRT-I complex subunit MVB12B; protein FAM125B (MVB12B, C9orf28, FAM125B)
tumor susceptibility gene 101 protein (TSG101)
vacuolar protein sorting-associated protein 28 (VPS28)
vacuolar protein sorting-associated protein 37D (Williams-Beuren syndrome region protein 24, VPS37D, WBSCR24)