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ESCRT-0 complex; STAM1/STAM2-HGS complex

Function: - complex binds ubiquitin & acts as sorting machinery that recognizes ubiquitinated receptors & transfers them to further sequential lysosomal sorting/trafficking processes Structure: - complex of STAM1 &/or STAM2 & HGS - EPS15 may also be part of the complex

General

molecular complex

Properties

SUBUNITS: signal transducing adapter molecule 1 COMPARTMENT: cytoplasm MOTIF: VHS domain {16-143} Ser phosphorylation site {S156} UIM {171-190} Tyr phosphorylation site {Y198} src homology 3 [SH3] domain SITE: 210-269 ITAM {370-387} MOTIF: Tyr phosphorylation site {Y381} Tyr phosphorylation site {Y384} signal transducing adapter molecule 2 COMPARTMENT: cytoplasm MOTIF: VHS domain {16-144} MOTIF: PxVxL {54-67} UIM {165-184} Tyr phosphorylation site {Y192} src homology 3 [SH3] domain SITE: 202-261 MOTIF: USP8 interaction {219-220} Tyr phosphorylation site {Y291} HGS interaction {334-368} ITAM {360-377} MOTIF: Tyr phosphorylation site {Y371} Tyr phosphorylation site {Y374} hepatocyte growth factor-regulated tyrosine kinase substrate COMPARTMENT: cytoplasm MOTIF: VHS domain {15-143} MOTIF: Tyr phosphorylation site {Y132} Zn finger Fyve-type SITE: 160-220 EFFECTOR-BOUND: Zn+2 MOTIF: Tyr phosphorylation site {Y216} SNX1 interaction {225-543} MOTIF: Ser phosphorylation site {S240} UIM {258-277} Tyr phosphorylation site {Y286} Tyr phosphorylation site {Y289} Tyr phosphorylation site {Y308} Tyr phosphorylation site {Y329} Tyr phosphorylation site {Y334} proline-rich region SITE: 346-394 MOTIF: proline residue (SEVERAL) SNAP25/TRAK2 interaction {445-543} STAM1 interaction {454-572} NF2 interaction {480-777} MOTIF: glutamine-rich region {505-772} MOTIF: glutamine residue (SEVERAL)

References

  1. UniProt :accession O14964
  2. UniProt :accession Q92783
  3. UniProt :accession O75886

Components

hepatocyte growth factor-regulated tyrosine kinase substrate; protein pp110 (Hrs, HGS) signal transducing adapter molecule 1 (STAM1) signal transducing adapter molecule 2; STAM-2; Hrs-binding protein (STAM2, HBP)