ER degradation-enhancing alpha-mannosidase-like 1 (EDEM1, EDEM, KIAA0212)

Function: 1) extracts misfolded glycoproteins from calnexin cycle 2) role in endoplasmic reticulum-associated degradation of glycoprotein 3) targets misfolded glycoproteins for degradation (N-glycan- dependent) 4) lacks mannosidase activity 5) interacts with DERL2 & DERL3 Structure: - belongs to the glycosyl hydrolase 47 family Compartment: edoplasmic reticulum membrane

General

glycoprotein membrane protein

Properties

SIZE: MW = 74 kD entity length = 657 aa COMPARTMENT: endoplasmic reticulum MOTIF: transmembrane domain {5-25} N-glycosylation site {N181} N-glycosylation site {N198} N-glycosylation site {N299} N-glycosylation site {N342} N-glycosylation site {N624}

Database Correlations

OMIM 607673 UniProt Q92611 Pfam PF01532

References

UniProt :accession Q92611