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erythrocyte osmotic fragility incubated

Indications: - evaluation of - hereditary spherocytosis - thalassemia Reference values: -> hemolysis occurs within range of 0.3-0.5% NaCl (normal saline is 0.9% NaCl) Clinical significance: - osmotic fragility is increased if hemolysis occurs in > 0.5% NaCl - osmotic fragility is decreased if hemolysis is incomplete in 0.3% NaCl Increases: - causes of increased osmotic fragility a) hereditary spherocytosis b) thalassemia

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erythrocyte osmotic fragility

General

clinical hematology test

References

  1. Medical Knowledge Self Assessment Program (MKSAP) 11, American College of Physicians, Philadelphia 1998
  2. Medline Plus: Osmotic fragility http://www.nlm.nih.gov/medlineplus/ency/article/003641.htm
  3. Osmotic Fragility Laboratory Test Directory ARUP: 2002257