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erythema infectiosum (5th disease)
Etiology: parvovirus B19
Epidemiology:
1) generally affects children 3-12 years of age
2) case in 11 month old [3]*
2) occurs in winter & spring
* ref [3] makes no reference to epidemiology
Clinical manifestations:
1) incubation period of 1 to 3 weeks
1) prodrome of mild fever, cough, malaise, nausea, & diarrhea coinciding with the onset of viremia lasts 2-3 days
2) prodromal symptoms generally precede appearance of rash
a) initial bright-red 'slapped-cheek' appearance (malar rash)
b) diffuse lacy reticular rash that waxes & wanes over 3 weeks
4) arthritis in adults, 10% of children
Management:
- symptomatic
- acetaminophen may reduce fever
Related
Dukes disease (4th disease)
erythema
measles (1st disease)
roseola (exanthem subitum, 6th disease)
rubella (German measles, 3rd disease)
scarlet fever (2nd disease)
General
viral infection
childhood exanthem (numbered diseases)
References
- Harrison's Principles of Internal Medicine, 14th ed.
Fauci et al (eds), McGraw-Hill Inc. NY, 1998, pg 91
- Mayo Internal Medicine Board Review, 1998-99, Prakash UBS (ed)
Lippincott-Raven, Philadelphia, 1998, pg 520
- NEJM Knowledge+. Question of the Week,
Physician's First Watch, July 21, 2015
David G. Fairchild, MD, MPH, Editor-in-Chief
Massachusetts Medical Society
http://www.jwatch.org
- Young NS and Brown KE.
Parvovirus B19.
N Engl J Med 2004 Feb 6; 350:586.
PMID: 14762186