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ERCC1/XPF heterodimer
Function:
- heterodimer with XPF (ERCC4)
- ERCC1/XPF is a structure-specific nuclease; it cleaves Y-type structures at the junction of DNA double-stranded & single-stranded regions
- ERCC1/XPF cuts on the strand that leads off from the junction in the 5'-3' direction
- ERCC1/XPF probably works in coordination with the XP G-correcting protein in excision repair, the two nucleases cleaving the same DNA strand on opposite sides of DNA damage
Related
DNA repair protein complementing XP-G cells; xeroderma pigmentosum group G-complementing protein; DNA excision repair protein ERCC-5 (ERCC5, ERCM2, XPG, XPGC)
General
endodeoxyribonuclease
molecular complex
Figures/Diagrams
Model for nucleotide excision repair (v2)
Properties
MOTIF: active site
SUBUNITS: DNA excision repair protein ERCC1
MOTIF: nuclear translocation signal {17-23}
binding site
SITE: 93-120
FOR-BINDING-OF: DNA repair protein complementing XP-A cells
DNA-binding motif
SITE: 134-156
binding site
EFFECTOR-BOUND: DNA repair endonuclease XPF
BOUND-VIA: binding site
binding site
SITE: 224-297
FOR-BINDING-OF: DNA repair endonuclease XPF
DNA repair endonuclease XPF
MOTIF: leucine zipper
SITE: 233-254
FOR-BINDING-VIA: leucine zipper
leucine zipper
SITE: 270-298
FOR-BINDING-VIA: leucine zipper
peptide motif {486-491}
Ser phosphorylation site {S520}
Ser phosphorylation site {S521}
Ser phosphorylation site {S524}
binding site
EFFECTOR-BOUND: DNA excision repair protein ERCC1
BOUND-VIA: binding site
EME1/ERCC1 {617-916}
References
- Lehmann AR.
Nucleotide excision repair and the link with transcription.
Trends Biochem Sci. 1995 Oct;20(10):402-5. Review.
PMID: 8533152
Components
DNA excision repair protein ERCC1; Excision Repair Cross Complement-1 protein (ERCC1)
DNA repair endonuclease XPF; DNA excision repair protein ERCC-4; DNA repair protein complementing XP-F cells; Xeroderma pigmentosum group F-complementing protein (ERCC4, ERCC11, XPF)