EGF receptor family protein or erbB proto-oncogene protein

Ligand binding induces homo- & hetero-dimerization of receptors & activation of intrinsic kinase domain resulting in autophosphorylation on cytoplasmic tail.

Specific

epidermal growth factor receptor; receptor tyrosine-protein kinase ErbB-1 (EGFR, ERBB1, HER1) receptor tyrosine-protein kinase erbB-2; p185erbB2; C-erbB-2; NEU proto-oncogene; tyrosine kinase-type cell surface receptor HER2; MLN 19; CD340 (ERBB2, HER2, NEU, NGL) receptor tyrosine-protein kinase erbB-3; c-erbB3; tyrosine kinase-type cell surface receptor HER3 (ERBB3, HER3) receptor tyrosine-protein kinase erbB-4; p180erbB4; tyrosine kinase-type cell surface receptor HER4 (ERBB4, HER4)

General

oligomerizing protein proto oncogene protein tyrosine kinase receptor (RTK)

Properties

COMPARTMENT: plasma membrane STATE: active state MOTIF: ligand-binding site transmembrane domain Tyr phosphorylation site kinase domain MOTIF: ATP-binding site NAME: ATP-binding site