equilibrative nucleoside transporter 2 (equilibrative nitrobenzylmercaptopurine riboside-insensitive nucleoside transporter, equilibrative NBMPR-insensitive nucleoside transporter, nucleoside transporter EI-type, 36 kD nucleolar protein HNP36, 36 kD hydrophobic nucleolar protein, delayed-early response protein 12, solute carrier family 29 {nucleoside transporter} member 2, SLC29A2)

Function: - mediates equilibrative transport of purine, pyrimidine nucleosides & the purine base hypoxanthine - less sensitive than SLC29A1 to inhibition by nitrobenzylthioinosine (NBMPR), dipyridamole, dilazep & draflazine Structure: belongs to the SLC29A transporter family Compartment: - isoform 1: cell membrane - isoform 2: nucleus membrane Alternative splicing: named isoforms=2 Expression: - expressed in placenta, brain, heart & ovarian tissues - induced by platelet-derived growth factor (PDGF) & fibroblast growth factor (FGF)

General

nuclear protein solute carrier family 29 (SLC29, SLC29A) transmembrane 11 protein

Properties

SIZE: entity length = 456 aa MW = 50 kD COMPARTMENT: plasma membrane MOTIF: transmembrane domain {13-33} N-glycosylation site {N48} N-glycosylation site {N57} transmembrane domain {70-90} transmembrane domain {99-119} transmembrane domain {124-144} transmembrane domain {162-182} transmembrane domain {193-213} N-glycosylation site {N225} transmembrane domain {291-311} transmembrane domain {324-344} transmembrane domain {360-380} transmembrane domain {386-406} transmembrane domain {432-452}

Database Correlations

OMIM 602110 UniProt Q14542 Pfam PF01733 Kegg hsa:3177

References

UniProt :accession Q14542