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epothilone
A group of 16-member macrolides.
Includes:
- epothilone A
- epothilone B
- epothilone C
- epothilone D
Mechanism of action:
- microtubule stabilization
- interaction with microtubules differs from taxanes
- promotes apoptosis
Synthethic & derived from myxobacterium Sorangium cellosum now renamed to Polyangium (Myxococaccales)
Interactions
drug adverse effects of macrolide(s)
Specific
epothilone A
epothilone B
epothilone C
epothilone D
General
epoxide
thiazole
macrolide (macrolide antibiotic)
antineoplastic agent (chemotherapeutic agent)
References
- NLM MeSH Browser
http://www.nlm.nih.gov/mesh/meshhome.html