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epithelial Ca+2 channel 1; transient receptor potential cation channel subfamily V member 5; TrpV5; Ca+2 transport protein 2; CaT2; ECaC; ECaC1; Osm-9-like TRP channel 3; OTRPC3 (TRPV5, ECAC1)
Function:
- constitutively active Ca+2 selective cation channel
- thought to be involved in Ca+2 reabsorption in kidney & intestine
- the channel is activated by low internal Ca+2 level & the current exhibits an inward rectification
- a Ca+2-dependent feedback regulation includes fast channel inactivation & slow current decay
- heteromeric assembly with TRPV6 seems to modify channel properties
- TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (putative)
- activated by WNK3
- homotetramer & probably heterotetramer with TRPV6
- interacts with TRPV6
- interacts with S100A10 & probably with the ANAX2-S100A10 heterotetramer
- interaction with S100A10 is required for the trafficking to the plasma membrane
- interacts with calmodulin
- interacts with BSPRY, which results in its inactivation (putative)
Structure:
- glycosylated
- belongs to the transient receptor (TC 1.A.4) family TrpV subfamily, TRPV5 sub-subfamily
- contains 5 ANK repeats
Compartment:
- apical cell membrane; multi-pass membrane protein
- colocalized with S100A10 & ANAX2 along the apical domain of kidney distal tubular cells (putative)
- glycosylated form in the cell membrane is increased by the presence of WNK3
Expression:
- expressed at high levels in kidney, small intestine & pancreas
- expressed at lower levels in testis, prostate, placenta, brain, colon & rectum
General
ankyrin repeat domain protein (ANKRD)
transient receptor potential cation channel subfamily V (TRPV)
Properties
SIZE: MW = 83 kD
entity length = 729 aa
COMPARTMENT: cellular membrane
MOTIF: cytoplasmic domain {1-328}
MOTIF: ankyrin repeat
NAME: ankyrin repeat
SITE: 44-74
ankyrin repeat
NAME: ankyrin repeat
SITE: 78-107
ankyrin repeat
NAME: ankyrin repeat
SITE: 116-145
ankyrin repeat
NAME: ankyrin repeat
SITE: 162-191
ankyrin repeat
NAME: ankyrin repeat
SITE: 239-268
transmembrane domain {329-349}
exoplasmic loop {350-387}
MOTIF: N-glycosylation site {N358}
transmembrane domain {388-408}
cytoplasmic loop {409-419}
transmembrane domain {420-440}
exoplasmic loop {441-448}
transmembrane domain {449-469}
cytoplasmic loop {470-492}
transmembrane domain {493-513}
exoplasmic loop {514-556}
transmembrane domain {557-577}
cytoplasmic domain {578-729}
MOTIF: S100A10 interaction {598-602}
Involved in Ca(2+)-dependent inactivation {650-653}
Involved in Ca(2+)-dependent inactivation {700-729}
ION-PERMEABILITY: Ca+2
Database Correlations
OMIM 606679
UniProt Q9NQA5
PFAM correlations
Entrez Gene 56302
Kegg hsa:56302
References
- UniProt :accession Q9NQA5
- SeattleSNPs
http://pga.gs.washington.edu/data/trpv5/