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epiregulin; contains: epiregulin; EPR (EREG)
Function:
- may be a mediator of localized cell proliferation
- as a mitogen, it may stimulate cell proliferation &/or angiogenesis
Structure: contains 1 EGF-like domain
Compartment:
- epiregulin: secreted, extracellular space
- proepiregulin: cell membrane
Expression:
- in normal adults, expressed predominantly in placenta & peripheral blood leukocytes
Pathology:
- high levels detected in serveral carcinomas
a) bladder carcinoma
b) lung carcinoma
c) renal cell carcinoma
d) colon carcinoma
General
growth factor
membrane protein
secreted protein
Properties
SIZE: entity length = 169 aa
MW = 19 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-29}
N-glycosylation site {N47}
EGF domain {64-104}
MOTIF: cysteine residue {C68}
MODIFICATION: cysteine residue {C81}
cysteine residue {C76}
MODIFICATION: cysteine residue {C92}
cysteine residue {C81}
MODIFICATION: cysteine residue {C68}
cysteine residue {C92}
MODIFICATION: cysteine residue {C76}
cysteine residue {C94}
MODIFICATION: cysteine residue {C103}
cysteine residue {C103}
MODIFICATION: cysteine residue {C94}
transmembrane domain {120-140}
lysine-rich region {145-152}
MOTIF: lysine residue (SEVERAL)
Database Correlations
OMIM 602061
UniProt O14944
Pfam PF00008
Entrez Gene 2069
Kegg hsa:2069
References
- UniProt :accession O14944
- Entrez Gene :accession 2069