epididymal sperm-binding protein 1 (epididymal secretory protein 12, hE12, ELSPBP1, E12)

Function: - binds to spermatozoa upon ejaculation & may play a role in sperm capacitation - has phosphorylcholine-binding activity - N-glycosylated Structure: - belongs to the seminal plasma protein family - contains 4 fibronectin type-2 domains Compartment: secreted Expression: - detected in cauda epididymidal fluid & on sperm membrane (at protein level)

Properties

SIZE: entity length = 223 aa MW = 26 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-24} fibronectin type II domain or F2 module SITE: 25-68 FOR-BINDING-OF: collagen MOTIF: cysteine residue {*1} MODIFICATION: cysteine residue {*3} cysteine residue {*2} MODIFICATION: cysteine residue {*4} cysteine residue {*3} MODIFICATION: cysteine residue {*1} cysteine residue {*4} MODIFICATION: cysteine residue {*2} fibronectin type II domain or F2 module SITE: 69-117 FOR-BINDING-OF: collagen MOTIF: cysteine residue {*1} MODIFICATION: cysteine residue {*3} cysteine residue {*2} MODIFICATION: cysteine residue {*4} cysteine residue {*3} MODIFICATION: cysteine residue {*1} cysteine residue {*4} MODIFICATION: cysteine residue {*2} cysteine residue {C74} MODIFICATION: cysteine residue {C100} cysteine residue {C88} MODIFICATION: cysteine residue {C115} cysteine residue {C100} MODIFICATION: cysteine residue {C74} cysteine residue {C115} MODIFICATION: cysteine residue {C88} fibronectin type II domain or F2 module SITE: 124-170 FOR-BINDING-OF: collagen MOTIF: cysteine residue {*1} MODIFICATION: cysteine residue {*3} cysteine residue {*2} MODIFICATION: cysteine residue {*4} cysteine residue {*3} MODIFICATION: cysteine residue {*1} cysteine residue {*4} MODIFICATION: cysteine residue {*2} cysteine residue {C129} MODIFICATION: cysteine residue {C153} cysteine residue {C143} MODIFICATION: cysteine residue {C168} cysteine residue {C153} MODIFICATION: cysteine residue {C129} cysteine residue {C168} MODIFICATION: cysteine residue {C143} fibronectin type II domain or F2 module SITE: 177-223 FOR-BINDING-OF: collagen MOTIF: cysteine residue {*1} MODIFICATION: cysteine residue {*3} cysteine residue {*2} MODIFICATION: cysteine residue {*4} cysteine residue {*3} MODIFICATION: cysteine residue {*1} cysteine residue {*4} MODIFICATION: cysteine residue {*2} cysteine residue {C182} MODIFICATION: cysteine residue {C208} N-glycosylation site {N195} cysteine residue {C196} MODIFICATION: cysteine residue {C223} cysteine residue {C208} MODIFICATION: cysteine residue {C182} cysteine residue {C223} MODIFICATION: cysteine residue {C196}

Database Correlations

OMIM 607443 UniProt Q96BH3 Pfam PF00040

References

UniProt :accession Q96BH3