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epidermal growth factor (EGF) receptor kinase substrate 8-like protein 2; EPS8-like protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2; EPS8-related protein 2 (EPS8L2, EPS8R2, PP13181)
Function:
1) stimulates guanine exchange activity of SOS1
2) membrane ruffling
3) remodelling of the actin cytoskeleton
4) interacts with ABI1, F-actin
5) component of complex that contains SOS1, ABI1, EPS8L2
Structure:
- belongs to the EPS8 family
- contains 1 PID domain
- contains 1 SH3 domain
Compartment: cytoplasm
Alternative splicing: named isoforms=2
Expression:
- detected in fibroblasts & placenta
General
epidermal growth factor receptor kinase substrate 8-like protein (EPS8-like protein, EPS8L)
phosphoprotein
Properties
SIZE: entity length = 715 aa
MW = 81 kD
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S8}
Ser phosphorylation site {S21}
phosphotyrosine interaction domain
NAME: phosphotyrosine interaction domain
SITE: 46-202
Ser phosphorylation site {S217}
Ser phosphorylation site {S240}
Ser phosphorylation site {S449}
Ser phosphorylation site {S459}
Thr phosphorylation site {T469}
Ser phosphorylation site {S480}
src homology 3 [SH3] domain
SITE: 492-551
Ser phosphorylation site {S570}
Database Correlations
UniProt Q9H6S3
PFAM correlations
Entrez Gene 64787
Kegg hsa:64787
References
UniProt :accession Q9H6S3