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epidermal growth factor (EGF) receptor kinase substrate 8-like protein 1; EPS8-like protein 1; epidermal growth factor receptor pathway substrate 8-related protein 1; EPS8-related protein 1 (EPS8L1 DRC3 EPS8R1 PP10566)
Function:
1) stimulates guanine exchange activity of SOS1
2) membrane ruffling
3) remodelling of the actin cytoskeleton
4) interacts with ABI1, F-actin
5) component of complex that contains SOS1, ABI1, EPS8L2
Structure:
- belongs to the EPS8 family
- contains 1 SH3 domain
Compartment: cytoplasm
Alternative splicing: named isoforms=2
Expression: expressed in placenta
General
epidermal growth factor receptor kinase substrate 8-like protein (EPS8-like protein, EPS8L)
Properties
SIZE: entity length = 723 aa
MW = 80 kD
COMPARTMENT: cytoplasm
MOTIF: Ser phosphorylation site {S182}
Thr phosphorylation site {T187}
arginine-rich region {448-451}
MOTIF: arginine residue (SEVERAL)
src homology 3 [SH3] domain
SITE: 478-537
proline-rich region
SITE: 534-576
MOTIF: proline residue (SEVERAL)
coiled coil {689-719}
Database Correlations
UniProt Q8TE68
PFAM correlations
Entrez Gene 54869
Kegg hsa:54869
References
UniProt :accession Q8TE68