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ephrin-B1; EPH-related receptor tyrosine kinase ligand 2; LERK-2; ELK ligand; ELK-L; EFL-3 (EFNB1, EFL3, EPLG2, LERK2)
Function:
- binds to ephB1 receptor & ephA1 receptor
- ephrin B1 induces association of EphB2 receptors with the NR1 subunit (glutamate receptor zeta) of the NMDA receptor & causes these subunits to cluster [2]
- binds to, & induce the collapse of, commissural axons & growth cones in vitro
- may play a role in constraining the orientation of longitudinally projecting axons
- inducible phosphorylation of Tyr in the cytoplasmic domain (putative)
- interacts with GRIP1 & GRIP2
Structure:
- belongs to the ephrin family
Compartment:
- membrane; single-pass type 1 membrane protein
Expression:
- heart, placenta, lung, liver, skeletal muscle, kidney, pancreas
- induced by TNF-alpha
Pathology:
- defects in EFNB1 are a cause of craniofrontonasal syndrome
Interactions
molecular events
General
ephrin B or ephrin B ligand
Properties
SIZE: entity length = 346 aa
MW = 38 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-27}
cysteine residue {C64}
MODIFICATION: cysteine residue {C101}
cysteine residue {C89}
MODIFICATION: cysteine residue {C153}
cysteine residue {C101}
MODIFICATION: cysteine residue {C64}
N-glycosylation site {N139}
cysteine residue {C153}
MODIFICATION: cysteine residue {C89}
transmembrane domain {238-258}
Ser phosphorylation site {S287}
Tyr phosphorylation site {Y313}
Tyr phosphorylation site {Y317}
PDZ recognition motif
NAME: PDZ recognition motif
SITE: 344-346
FOR-BINDING-VIA: PDZ domain
Database Correlations
OMIM correlations
UniProt P98172
Pfam PF00812
Entrez Gene 1947
Kegg hsa:1947
References
- Eph Nomenclature Committee. Cell 90:403-4 1997
- Ghosh A.
Neurobiology. Learning more about NMDA receptor regulation.
Science. 2002 Jan 18;295(5554):449-51. No abstract available.
PMID: 11799227
- OMIM :accession 604597
- Entrez Gene :accession 1947
- UniProt :accession P98172
- GeneReviews
http://www.ncbi.nlm.nih.gov/sites/genetests/lab/gene/EFNB1
Component-of
molecular complex