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ephexin (eph interacting exchange factor)
Function:
- ephexin activity related to ephrin A stimulation of Eph A receptors, leading to rho A activation, cdc42 & Rac1 inhibition
- mediates ephrin induced growth cone collapse
Structure:
- member of Dbl family of guanine nucleotide exchange factors for rho GTPases
Related
eph family receptor
ephrin A or ephrin A ligand
Specific
ephexin-1 (Eph-interacting exchange protein, neuronal guanine nucleotide exchange factor, NGEF)
General
guanine nucleotide exchange factor (GDP/GTP dissociation stimulator, guanine nucleotide-releasing factor/protein, GNEF, GNDS, GDS)
Properties
MOTIF: guanine nucleotide exchange domain
NAME: guanine nucleotide exchange domain
References
- Shamah SM et al.
EphA receptors regulate growth cone dynamics through the novel
guanine nucleotide exchange factor ephexin.
Cell 105:233-44 2001
PMID: 11336673