Search
ephB receptor
Function:
- selectively activated by ephrin-B ligands
- binding of ephrin B results in phosphorylation of cytoplasmic Tyr(s) in both the ephB receptor & ephrin B; this serves as a bidirectional signal between presynaptic & postsynaptic terminals
- activation of the EphB receptor potentiates glutamate- induced Ca+2 influx through the NMDA receptor
Interactions
molecular events
Related
ephrin B or ephrin B ligand
Specific
ephB5 receptor
ephrin type-B receptor 1; tyrosine-protein kinase receptor EPH-2; NET; HEK6; ELK (EPHB1, EPHT2, NET)
Ephrin type-B receptor 2; tyrosine-protein kinase receptor EPH-3; DRT; receptor protein-tyrosine kinase HEK5; ERK; tyrosine-protein kinase TYRO5; renal carcinoma antigen NY-REN-47 (EPHB2; DRT; EPHT3; EPTH3; ERK; HEK5; TYRO5)
Ephrin type-B receptor 3; tyrosine-protein kinase receptor HEK-2; tyrosine-protein kinase TYRO6 (EPHB3, ETK2, HEK2, TYRO6)
Ephrin type-B receptor 4; hepatoma transmembrane kinase; tyrosine-protein kinase receptor HTK; tyrosine-protein kinase TYRO11 (EPHB4, HTK, TYRO11)
ephrin type-B receptor 6; tyrosine-protein kinase-defective receptor EPH-6; HEP (EPHB6)
General
eph family receptor
Properties
COMPARTMENT: plasma membrane
STATE: active state
MOTIF: ligand-binding site
cysteine-rich region
fibronectin type III domain or F3 module (2)
transmembrane domain
membrane region
kinase domain
MOTIF: ATP-binding site
NAME: ATP-binding site
Tyr phosphorylation site
binding site
FOR-BINDING-OF: ephrin
MOTIF: immunoglobulin superfamily domain
PDZ recognition motif
NAME: PDZ recognition motif
SITE: C-TERMINUS
FOR-BINDING-VIA: PDZ domain
References
- Ghosh A.
Neurobiology. Learning more about NMDA receptor regulation.
Science. 2002 Jan 18;295(5554):449-51. No abstract available.
PMID: 11799227
Component-of
molecular complex