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Ephrin type-B receptor 4; hepatoma transmembrane kinase; tyrosine-protein kinase receptor HTK; tyrosine-protein kinase TYRO11 (EPHB4, HTK, TYRO11)

Function: - receptor for members of the ephrin-B family - binds to ephrin-B2 - may have a role in events mediating differentiation & development - autophosphorylated Structure: - belongs to the protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily - contains 2 fibronectin F3 modules - contains 1 protein kinase domain - contains 1 SAM (sterile alpha motif) domain Compartment: membrane Expression: - abundantly expressed in placenta - expressed in many normal tissues & malignant cell lines - expressed in fetal brain, but not adult brain - expressed in hematopoietic precursors & myeloid cells - not expressed in lymphocytes

Related

hepatoma

General

ephB receptor glycoprotein

Properties

SIZE: entity length = 987 aa MW = 108 kD COMPARTMENT: cellular membrane STATE: active state MOTIF: signal sequence {1-15} cysteine-rich region {184-320} MOTIF: N-glycosylation site {N203} fibronectin type III domain or F3 module {323-428} MOTIF: N-glycosylation site {N335} N-glycosylation site {N426} fibronectin type III domain or F3 module {434-526} transmembrane domain {540-560} kinase domain SITE: 615-899 MOTIF: ATP-binding site NAME: ATP-binding site SITE: 621-629 ATP-binding site NAME: ATP-binding site SITE: 647-647 aspartate residue {D740} Ser phosphorylation site {S769} sterile alpha motif NAME: sterile alpha motif SITE: 907-971 MOTIF: Ser phosphorylation site {S911} Thr phosphorylation site {T953} Thr phosphorylation site {T976} PDZ recognition motif NAME: PDZ recognition motif SITE: 985-987 FOR-BINDING-VIA: PDZ domain

Database Correlations

OMIM 600011 UniProt P54760 PFAM correlations Entrez Gene 2050 Kegg hsa:2050 ENZYME 2.7.10.1

References

  1. UniProt :accession P54760
  2. Eph Nomenclature Committee. Cell 90:403-4 1997