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Ephrin type-B receptor 3; tyrosine-protein kinase receptor HEK-2; tyrosine-protein kinase TYRO6 (EPHB3, ETK2, HEK2, TYRO6)
Function:
- receptor for members of the ephrin-B family, binds to ephrin-B1 & -B2
Structure:
- belongs to the protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
- contains 2 fibronectin F3 modules
- contains 1 protein kinase domain
- contains 1 SAM (sterile alpha motif) domain
Compartment: membrane
Expression: ubiquitous
General
ephB receptor
glycoprotein
Properties
SIZE: entity length = 998 aa
MW = 110 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-33}
cysteine-rich region {199-336}
fibronectin type III domain or F3 module {340-443}
MOTIF: N-glycosylation site {N351}
N-glycosylation site {N445}
fibronectin type III domain or F3 module {453-544}
transmembrane domain {560-580}
Tyr phosphorylation site {Y600}
kinase domain
SITE: 633-896
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 639-647
ATP-binding site
NAME: ATP-binding site
SITE: 665-665
aspartate residue {D758}
sterile alpha motif
NAME: sterile alpha motif
SITE: 925-989
PDZ recognition motif
NAME: PDZ recognition motif
SITE: 996-998
FOR-BINDING-VIA: PDZ domain
Database Correlations
OMIM 601839
UniProt P54753
PFAM correlations
Entrez Gene 2049
Kegg hsa:2049
ENZYME 2.7.10.1
References
- UniProt :accession P54753
- Eph Nomenclature Committee. Cell 90:403-4 1997