EP300-interacting inhibitor of differentiation 2 (EID-2, EID-1-like inhibitor of differentiation 2, CREBBP/EP300 inhibitor 2, EID2, CRI2)

Function: - interacts with EP300 - acts as a repressor of MYOD- dependent transcription & muscle differentiation - inhibits EP300 histone acetyltransferase activity - acts as a repressor of TGFB/SMAD transcriptional responses - may act as a repressor of the TGFB/SMAD3-dependent signaling by selectively blocking formation of TGFB-induced SMAD3-SMAD4 complex - heterodimer with EID2B - interacts with the C-terminus of EP300 - interacts with HDAC1 & HDAC2 - interacts with SMAD2, SMAD4 & with the MH2 domain of SMAD3 Structure: - N-terminal portion of EID2 is required for nuclear localization Compartment: nucleus Alternative splicing: named isoforms=2 Expression: - most abundantly expressed in placenta - highly expressed in liver, brain, heart, skeletal muscle, & kidney

Properties

SIZE: entity length = 236 aa MW = 25 kD COMPARTMENT: cell nucleus MOTIF: alanine-rich region {35-109} MOTIF: alanine residue (SEVERAL) coiled coil {170-190}

Database Correlations

UniProt Q8N6I1 Kegg hsa:1631

References

UniProt :accession Q8N6I1