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eotaxin; C-C motif chemokine 11; eosinophil chemotactic protein; small-inducible cytokine A11 (CCL11, SCYA11)
Function:
- chemotactic for eosinophils
- promotes accumulation of eosinophils response to allergens
- binds to CCR3
Structure:
- O-linked glycan
- consists of a gal-galNAc disaccharide which mofified with up to 2 sialic acid residues
- belongs to the intercrine beta (chemokine CC) family
Compartment: secreted
Expression:
- induced by TNF, IL1A/interleukin-1 alpha & IFNG/IFN-gamma
- levels increase in blood & CSF with age (in humans) [4]
Laboratory:
- CCL11 in CSF may be a marker for chronic traumatic encephalopathy
Comparative biology:
- may inhibit learning, memory, & neurogenesis during aging in mice [4]
General
CC chemokine; beta chemokine
glycoprotein
Properties
SIZE: entity length = 97 aa
MW = 11 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-23}
cysteine residue {C32}
MODIFICATION: cysteine residue {C57}
cysteine residue {C33}
MODIFICATION: cysteine residue {C73}
cysteine residue {C57}
MODIFICATION: cysteine residue {C32}
cysteine residue {C73}
MODIFICATION: cysteine residue {C33}
Thr glycosylation site {T94}
References
- UniProt :accession P51671
- R&D systems' cytokine source book: CCL11
http://www.rndsystems.com/molecule_detail.aspx?m=1367
- Wikipedia; Note: CCL11 entry
http://en.wikipedia.org/wiki/CCL11
- Villeda SA et al.
The ageing systemic milieu negatively regulates neurogenesis
and cognitive function.
Nature 2011 Sep; 477:90
PMID: 21886162
Databases & Figures
OMIM 601156
UniProt P51671
Pfam PF00048
Entrez Gene 6356
Kegg hsa:6356
CC ligand and receptor binding