eosinophil lysophospholipase; Charcot-Leyden crystal protein; lysolecithin acylhydrolase; galectin-10 (CLC)

Function: - may have both lysophospholipase & carbohydrate-binding activities 2-lysophosphatidylcholine + H2O glycerophosphocholine + a carboxylate Structure: contains 1 galectin domain Compartment: - cytoplasmic granule - localized in granules from where it may be secreted or transported to other locations in the cell Expression: - expressed exclusively by eosinophils & basophils - not detected in monocytes & neutrophils Pathology: - forms hexagonal bipyramidal crystals, known as Charcot-Leyden crystals, in tissues & secretions from sites of eosinophil-associated inflammation & some myeloid leukemias

General

galaptin, galectin, galactoside-binding lectin, lactose-binding lectin or S-lectin lysophospholipase

Properties

SIZE: entity length = 142 aa MW = 16 kD COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl Galectin {6-138} MOTIF: binding site FOR-BINDING-OF: galactoside MOTIF: tryptophan residue asparagine residue {136} SECRETED-BY: eosinophil

Database Correlations

OMIM 153310 UniProt Q05315 Entrez Gene 1178 Kegg hsa:1178 ENZYME 3.1.1.5

References

UniProt :accession Q05315