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envoplakin; 210 kD paraneoplastic pemphigus antigen; 210 kD cornified envelope protein; p210 (EVPL)
Function:
- component of the cornified envelope of keratinocytes
- may link the cornified envelope to desmosomes & intermediate filaments
- substrate of transglutaminase
- some Glu & Lys are cross-linked to other envoplakin molecules, to other proteins such as keratin, desmoplakin, periplakin & involucrin, & to lipids like omega-hydroxyceramide
- may form a homodimer or a heterodimer with periplakin (PPL)
Structure:
- belongs to the plakin or cytolinker family
- contains 7 plectin repeats
- contains 1 spectrin repeat
Compartment:
- cell junction, desmosome, cornified envelope
- cytoplasm, cytoskeleton
- colocalized with DSP at desmosomes & along intermediate filaments
Expression:
- exclusively expressed in stratified squamous epithelia
- expressed during differentiation of epidermal keratinocytes
Related
desmosome
intermediate filament
keratinocyte
periplakin; 195 kD cornified envelope protein; 190 kD paraneoplastic pemphigus antigen (PPL, KIAA0568)
General
antigen
cytoskeletal protein
oligomerizing protein
phosphoprotein
Properties
SIZE: entity length = 2033 aa
MW = 232 kD
COMPARTMENT: cytoplasm
MOTIF: Globular 1 {1-841}
MOTIF: K-G-S-P tandem repeat {12-28}
spectrin repeat {229-330}
Central fibrous rod {842-1673}
MOTIF: coiled coil {845-1135}
Plectin {1185-1226}
Thr phosphorylation site {T1455}
Globular 2 {1674-2033}
MOTIF: Plectin {1678-1713}
Plectin {1818-1855}
Plectin {1856-1893}
Plectin {1894-1931}
Plectin {1932-1969}
Plectin {1970-2007}
Database Correlations
OMIM 601590
UniProt Q92817
Pfam PF00681
Entrez Gene 2125
Kegg hsa:2125
References
UniProt :accession Q92817