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enterovirus 71 vaccine
Indications:
- immunization against enterovirus 71*
- children age 6-35 months [2]
* common cause of hand, foot, & mouth disease & other illnesses, including herpangina, viral meningitis, especially in the Asia-Pacific region
Dosage:
- 2 IM injections 4 weeks apart
Notes:
- vaccine efficacy is 95% against enterovirus 71 infection, & 100% in preventing hospitalization & & neurologic complications [2]
General
vaccine
References
- Zhu FC et al
Efficacy, safety, and immunology of an inactivated alum-adjuvant
enterovirus 71 vaccine in children in China: a multicentre,
randomised, double-blind, placebo-controlled, phase 3 trial.
The Lancet. May 29, 2013
PMID: 23726161
http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(13)61049-1/abstract
- Zhu F et al.
Efficacy, safety, and immunogenicity of an enterovirus 71
vaccine in China.
N Engl J Med 2014 Feb 27; 370:818
PMID: 24571754
http://www.nejm.org/doi/full/10.1056/NEJMoa1304923
- Li R et al.
An inactivated enterovirus 71 vaccine in healthy children.
N Engl J Med 2014 Feb 27; 370:829.
PMID: 24571755
http://www.nejm.org/doi/full/10.1056/NEJMoa1303224