Search
3,2-trans enoyl CoA isomerase; dodecenoyl CoA delta-isomerase (DCI, ECI1)
Function:
- converts cis or trans beta-gamma unsaturated fatty acyl CoA derivatives to trans alpha-beta unsaturated isomers
- able to isomerize both 3-cis & 3-trans double bonds into the 2-trans form in a range of enoyl-CoA species
- fatty acid beta-oxidation cycle; auxiliary isomerization steps (3Z)-dodec-3-enoyl-CoA = (2E)-dodec-2-enoyl-CoA
Structure:
- homodimer (putative)
- belongs to the enoyl-CoA hydratase/isomerase family
Compartment: mitochondrial matrix
Alternative splicing: named isoforms=2
Interactions
molecular events
Specific
bifunctional peroxisomal enzyme [includes: enoyl-CoA hydratase/3,2-trans-enoyl-CoA isomerase; 3-hydroxyacyl-CoA dehydrogenase] (PBE, PBFE, EHHADH, ECHD)
delta(3,5)-delta(2,4)-dienoyl-CoA isomerase, mitochondrial (ECH1)
General
isomerase
mitochondrial protein
Properties
SIZE: entity length = 302 aa
MW = 33 kD
COMPARTMENT: mitochondrial matrix
MOTIF: active site
Database Correlations
UniProt P42126
Pfam PF00378
ENZYME 5.3.3.8
References
- Textbook of Biochemistry with Clinical Correlations,
3rd ed., TM Devlin (ed), Wiley-Liss, NY 1992 pg 413
- UniProt :accession P42126