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ENL (eleven-nineteen leukemia) proto oncogene protein; protein ENL; YEATS domain-containing protein 1 (MLLT1 ENL LTG19 YEATS1)
Function:
- capable of activating transcription from synthetic reporter genes in both lymphoid & myeloid cells
Structure: contains 1 YEATS domain
Compartment: nucleus
Pathology:
- chromosomal translocation t(11;19)(q23;p13.3) involving MLLT1 with MLL/HRX is associated with acute leukemias; the result is a rogue activator protein
Related
eleven-nineteen leukemia (ENL) gene
General
nuclear protein
phosphoprotein
proto oncogene protein
Properties
SIZE: entity length = 559 aa
MW = 62 kD
COMPARTMENT: cell nucleus
MOTIF: YEATS {8-112}
Ser phosphorylation site {S155}
Ser phosphorylation site {S209}
proline-rich region
SITE: 272-280
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S292}
Ser phosphorylation site {S296}
Ser phosphorylation site {S315}
serine-rich region {319-325}
MOTIF: serine residue (SEVERAL)
Ser phosphorylation site {S359}
Ser phosphorylation site {S361}
Ser phosphorylation site {S366}
serine-rich region {374-389}
MOTIF: serine residue (SEVERAL)
proline-rich region
SITE: 457-460
MOTIF: proline residue (SEVERAL)
proline-rich region
SITE: 463-466
MOTIF: proline residue (SEVERAL)
Ser phosphorylation site {S475}
Database Correlations
OMIM 159556
UniProt Q03111
Pfam PF03366
Entrez Gene 4298
Kegg hsa:4298
References
- UniProt :accession Q03111
- Atlas of Genetics & Cytogenetics in Oncology & Haematology
http://atlasgeneticsoncology.org/genes/ENL.html
Component-of
SWI/SNF-like EPAFb chromatin remodeling complex