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engulfment & cell motility protein 3 (ELMO3)
Function:
1) role in cytoskeletal rearrangements required for phagocytosis of apoptotic cells & cell motility
2) acts in association with DOCK1 & CRK
3) interacts directly with the SH3-domain of DOCK1 via its SH3-binding site
4) component of a complex with DOCK1 & RAC1
5) may enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1
Structure:
- contains 1 ELMO domain
- contains 1 PH domain
Compartment: cytoplasm
General
engulfment & cell motility protein (ELMO)
Properties
SIZE: MW = 69 kD
entity length = 607 aa
COMPARTMENT: cytoplasm
MOTIF: ELMO {193-365}
PH domain {429-551}
SH3-binding site
NAME: SH3-binding site
SITE: 583-593
Database Correlations
OMIM 606422
UniProt Q96BJ8
Pfam PF04727
References
UniProt :accession Q96BJ8