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engulfment & cell motility protein 2 (CED-12 homolog A, hCED-12A, ELMO2, CED12A, KIAA1834)
Function:
1) role in cytoskeletal rearrangements required for phagocytosis of apoptotic cells & cell motility
2) acts in assocation with DOCK1 & CRK
3) interacts with the SH3-domain of DOCK1 via its SH3-binding site
4) component of a complex with DOCK1 & RAC1
5) component of a complex with DOCK1 & CRK isoform CRK-II
6) may enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1
Structure:
- contains 1 ELMO domain
- contains 1 PH domain
Compartment: cytoplasm
Alternative splicing: named isoforms=2
Expression:
- widely expressed, higher expression in skeletal muscle, kidney, placenta
General
engulfment & cell motility protein (ELMO)
Properties
SIZE: MW = 83 kD
entity length = 720 aa
COMPARTMENT: cytoplasm
MOTIF: Tyr phosphorylation site {Y48}
ELMO {310-484}
PH domain {553-674}
SH3-binding site
NAME: SH3-binding site
SITE: 700-707
Database Correlations
OMIM 606421
UniProt Q96JJ3
Pfam PF04727
References
UniProt :accession Q96JJ3