Search
endothelin-converting enzyme-like 1 (Xce protein, ECEL1, XCE, UNQ2431/PRO4991)
Function:
1) degradation of peptide hormones
2) inactivation of neuronal peptides.
Structure:
1) binds 1 Zn+2
2) N-glycosylated
Compartment: membrane
Alternative splicing: named isoforms=2
Expression:
- expressed in CNS, including putamen, spinal cord, medulla & subthalamic nucleus > amygdala, caudate, thalamus > substantia nigra, cerebellum, cortex, corpus callosum, hippocampus
- also expressed in uterine subepithelial cells, renal blood vessels, pancreas, skeletal muscle
General
glycoprotein
membrane
metalloprotease
Properties
SIZE: MW = 88 kD
entity length = 775 aa
MOTIF: transmembrane domain {60-82}
N-glycosylation site {N255}
N-glycosylation site {N322}
Zn+2-binding site
SITE: 612-612
glutamate residue {E613}
Zn+2-binding site
SITE: 616-616
N-glycosylation site {N656}
Zn+2-binding site
SITE: 672-672
Database Correlations
OMIM 605896
UniProt O95672
PFAM correlations
References
UniProt :accession O95672