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endothelial lipase; endothelial cell-derived lipase; EDL; EL (LIPG)
Function:
1) phospholipase & triglyceride lipase activities
2) hydrolyzes high density lipoproteins (HDL)
3) binds heparin
4) inhibited by serum
Structure:
- head to tail homodimer
- belongs to the AB hydrolase superfamily, lipase family
- contains 1 PLAT domain
Compartment: secreted
Alternative splicing: named isoforms=2
Expression:
- synthesized in endothelial cells
- also expressed in other cell types
- expressed in liver, placenta, lung, thyroid, kidney, testis, corpus luteum of ovary, coronary artery endothelial cells, umbilical vein endothelial cells, hepatocyte & osteosarcoma cell lines
- not detected in heart, brain, muscle
General
glycoprotein
lipase
secreted protein
Properties
SIZE: MW = 57 kD
entity length = 500 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
cysteine residue {C64}
MODIFICATION: cysteine residue {C77}
cysteine residue {C77}
MODIFICATION: cysteine residue {C64}
N-glycosylation site {N80}
N-glycosylation site {N136}
serine residue {S169}
aspartate residue {D193}
cysteine residue {C252}
MODIFICATION: cysteine residue {C272}
cysteine residue {C272}
MODIFICATION: cysteine residue {C252}
histidine residue {H274}
cysteine residue {C297}
MODIFICATION: cysteine residue {C316}
cysteine residue {C308}
MODIFICATION: cysteine residue {C311}
cysteine residue {C311}
MODIFICATION: cysteine residue {C308}
cysteine residue {C316}
MODIFICATION: cysteine residue {C297}
binding site
SITE: 325-337
FOR-BINDING-OF: heparin
PLAT {347-482}
MOTIF: N-glycosylation site {N393}
cysteine residue {C463}
MODIFICATION: cysteine residue {C483}
N-glycosylation site {N469}
cysteine residue {C483}
MODIFICATION: cysteine residue {C463}
N-glycosylation site {N491}
Database Correlations
OMIM 603684
UniProt Q9Y5X9
PFAM correlations
Entrez Gene 9388
Kegg hsa:9388
ENZYME 3.1.1.3
References
UniProt :accession Q9Y5X9