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endothelial cell-specific molecule 1 (ESM-1 secretory protein, ESM-1, ESM1)
Function:
- role in lung endothelial cell-leukocyte interactions
Structure:
- monomer
- may contain intrachain disulfide bonds.
- contains 1 IGFBP domain
Compartment: secreted
Expression:
- expressed in lung, on vascular capillary network within alveolar walls > kidney
- induced by TNF-alpha & IL-1 beta, but not IL-4
General
secreted protein
Properties
SIZE: MW = 20 kD
entity length = 184 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-19}
IGFBP {28-88}
Database Correlations
OMIM 601521
UniProt Q9NQ30
Pfam PF00219
References
UniProt :accession Q9NQ30