Contents

Search

endostatin

Function: - inhibits angiogenesis, endothelial proliferation & tumor growth - may inhibit angiogenesis by binding to the heparan sulfate proteoglycans involved in growth factor signaling Expression: - seems to be derived from either - collagen 15 alpha-1 - C-terminal fragment of collagen 18 alpha-1

Related

collagen 15 alpha-1; contains: endostatin; restin (COL15A1) collagen 18 alpha-1; contains: endostatin (COL18A1)

General

endogenous angiogenesis inhibitor secreted protein

Properties

COMPARTMENT: extracellular compartment SIZE: MW = 20 kD entity length = 184 aa

References

  1. UniProt :accession P39059
  2. UniProt :accession P39060
  3. O'Reilly MS et al Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell. 1997 Jan 24;88(2):277-85. PMID: 9008168