endosomal sorting complex required for transport-3 (ESCRT3)

Function: 1) multivesicular body pathway 2) formation & sorting of endosomal cargo proteins into MVBs 3) chromosome condensation (putative) [2] - targets PCGF4 to regions of condensed chromatin 4) stable cell cycle progression [2] 5) PcG gene silencing [2] 6) recruits ESCRT2 complex Pathology: - HIV-1 virus takes advantage of ESCRT3 for budding & exocytic cargos of viral proteins

Properties

COMPARTMENT: endosome SUBUNITS: charged multivesicular body protein 1A COMPARTMENT: cytoplasm cell nucleus MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl coiled coil {5-47} coiled coil {102-124} MIT-interacting {185-195} charged multivesicular body protein 1B COMPARTMENT: endosome MOTIF: coiled coil {26-48} IST1 interaction {132-156} (COILED_COIL SITE ((RANGE LOW 178 HIGH 199)) MOTIF ((DOMAIN SITE ((RANGE LOW 180 HIGH 199)) NAME VTA1 interaction ENGLISH Interaction with VTA1) (DOMAIN SITE ((RANGE LOW 180 HIGH 196)) NAME VPS4A/MITD1/STAMBP interaction ENGLISH Interaction with VPS4A, MITD1 & STAMBP) (DOMAIN SITE ((RANGE LOW 183 HIGH 199)) NAME VPS4B interaction ENGLISH Interaction with VPS4B) (PEPTIDE_MOTIF SITE ((RANGE LOW 186 HIGH 196)) NAME MIT-interacting))) charged multivesicular body protein 2A COMPARTMENT: endosome MOTIF: acetylation site SITE: 1-1 EFFECTOR-BOUND: acetyl coiled coil {12-53} coiled coil {195-222} MOTIF: Ser phosphorylation site {S203} MIT-interacting {210-220} VTA1 interaction {217-222} charged multivesicular body protein 2B COMPARTMENT: cytoplasm MOTIF: coiled coil {25-55} Ser phosphorylation site {S199} MIT-interacting {201-211} charged multivesicular body protein 3 COMPARTMENT: cytoplasm MOTIF: domain {2-113} MOTIF: myristoylation site SITE: G2 EFFECTOR-BOUND: myristate coiled coil {22-54} valine residue {48} domain {59-64} Ser phosphorylation site {S116} Thr phosphorylation site {T126} coiled coil {141-222} MOTIF: VPS4A interaction {151-222} intramolecular interaction {151-220} domain {168-169} Ser phosphorylation site {S200} MIT-interacting {201-211} STAMBP interaction {203-207} binding site SITE: 216-216 FOR-BINDING-OF: STAM-binding protein STAMBP interaction {221-222} charged multivesicular body protein 4A COMPARTMENT: cytoplasm MOTIF: Intramolecular interaction with C- terminus {1-150} MOTIF: phosphoinosides interaction {1-116} coiled coil {20-105} Intramolecular interaction with N- terminus {151-222} MOTIF: coiled coil {155-180} charged multivesicular body protein 4B COMPARTMENT: cytoplasm MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl coiled coil {23-183} charged multivesicular body protein 4C COMPARTMENT: cytoplasm MOTIF: domain {1-153} coiled coil {125-183} domain {154-233} charged multivesicular body protein 5 COMPARTMENT: cytoplasm MOTIF: coiled coil {26-179} MOTIF: VTA1 interaction {121-158} Ser phosphorylation site {S219} charged multivesicular body protein 6 COMPARTMENT: endosome MOTIF: myristoylation site SITE: G2 EFFECTOR-BOUND: myristate coiled coil {10-145} peptide motif {168-179} VPS4A interaction {170-181}

Components

charged multivesicular body protein 1A; chromatin-modifying protein 1a; CHMP1a; vacuolar protein sorting-associated protein 46-1; Vps46-1; hVps46-1 (CHMP1A, CHMP1, KIAA0047, PCOLN3, PRSM1) charged multivesicular body protein 1B; CHMP1.5; chromatin-modifying protein 1B; CHMP1b; vacuolar protein sorting-associated protein 46-2; Vps46-2; hVps46-2 (CHMP1B, C18orf2) charged multivesicular body protein 2A; chromatin-modifying protein 2a; CHMP2a; breast adenocarcinoma marker BC-2; vacuolar protein sorting-associated protein 2-1; Vps2-1; hVps2-1 (CHMP2A, BC2, CHMP2) charged multivesicular body protein 2B; CHMP2.5; chromatin-modifying protein 2b; CHMP2b; vacuolar protein sorting-associated protein 2-2; Vps2-2; hVps2-2 (CHMP2B) charged multivesicular body protein 3; chromatin-modifying protein 3; neuroendocrine differentiation factor; vacuolar protein sorting-associated protein 24; hVps24 (CHMP3, CGI149, NEDF, VPS24, CGI-149) charged multivesicular body protein 4A; chromatin-modifying protein 4a; CHMP4a; SNF7 homolog associated with Alix-2; SNF7-1; hSnf-1; vacuolar protein sorting-associated protein 32-1; Vps32-1; hVps32-1 (CHMP4A, C14orf123, SHAX2, CDA04, HSPC134) charged multivesicular body protein 4B; chromatin-modifying protein 4B; CHMP4b; SNF7 homolog associated with Alix 1; SNF7-2; hSnf7-2; vacuolar protein sorting-associated protein 32-2; Vps32-2; hVps32-2 (CHMP4B, C20orf178, SHAX1) charged multivesicular body protein 4C; chromatin-modifying protein 4c; CHMP4c; SNF7 homolog associated with Alix 3; SNF7-3; hSnf7-3; vacuolar protein sorting-associated protein 32-3; Vps32-3; hVps32-3 (CHMP4C, SHAX3) charged multivesicular body protein 5; chromatin-modifying protein 5; SNF7 domain-containing protein 2; vacuolar protein sorting-associated protein 60; Vps60; hVps60 (CHMP5, C9orf83, SNF7DC2, CGI-34, HSPC177, PNAS-11,4 PNAS-2) charged multivesicular body protein 6; chromatin-modifying protein 6; vacuolar protein sorting-associated protein 20; Vps20; hVps20 (CHMP6, VPS20)