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endosomal sorting complex required for transport-2 (ESCRT2)

Function: 1) multivesicular body pathway - formation & sorting of endosomal cargo proteins into multivesicular bodies 2) transcription regulation, via interaction with ELL (putative) 3) recruited by ESCRT3 complex Structure: - consists of: SNF8, VPS25 & VPS36

General

molecular complex

Properties

COMPARTMENT: endosome SUBUNITS: vacuolar sorting protein SNF8 MOTIF: coiled coil {27-53} vacuolar protein sorting-associated protein 25 vacuolar protein sorting-associated protein 36 MOTIF: GLUE {1-138} coiled coil {160-185}

References

  1. UniProt :accession Q96FZ7

Components

vacuolar protein sorting-associated protein 25 (vesicle protein sorting 25, ELL-associated protein of 20 kD, dermal papilla-derived protein 9, hVPS25, VPS25, DERP9, EAP20) vacuolar protein sorting-associated protein 36 (VPS36, ELL-associated protein of 45 kD, C13orf9, EAP45, CGI-145) vacuolar sorting protein SNF8; ELL-associated protein of 30 kD (SNF8, EAP30)