Search
endoplasmic reticulum aminopeptidase 2 (leukocyte-derived arginine aminopeptidase, L-RAP, ERAP2, LRAP)
Function:
- aminopeptidase
- role in peptide trimming
- preferentially hydrolyzes the basic residues Arg & Lys heterodimer; with ERAP1
Cofactor: binds 1 Zn+2 per subunit (putative)
Structure:
- N-glycosylated
- belongs to the peptidase M1 family
Compartment:
- endoplasmic reticulum membrane
Alternative splicing: named isoforms=4
Expression:
- ubiquitously expressed
- highly expressed in spleen & leukocytes
- induced by IFN-gamma
Pathology:
- defects in the expression of this gene may cause improper antigen processing, possibly leading to favor tumor escape from the immune surveillance
Related
endoplasmic reticulum aminopeptidase (ERAP)
General
aminopeptidase
glycoprotein
membrane protein
Properties
SIZE: entity length = 960 aa
MW = 110 kD
COMPARTMENT: endoplasmic reticulum
MOTIF: transmembrane domain {21-40}
N-glycosylation site {N85}
N-glycosylation site {N119}
Zn+2-binding site
SITE: 370-370
glutamate residue {E371}
Zn+2-binding site
SITE: 374-374
N-glycosylation site {N405}
tyrosine residue {Y455}
Database Correlations
UniProt Q6P179
Pfam PF01433
References
UniProt :accession Q6P179