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endonuclease G (ENDOG)
Function:
- double-stranded DNA & single-stranded DNA endonuclease activity.
- able to generate RNA primers required by DNA polymerase gamma for initiating replication of mitochondrial DNA
- in addition to deoxyribonuclease activities, also has ribonuclease (Rnase) & Rnase H activities
Cofactor: Mn+2 or Mg+2
Structure:
- homodimer (putative)
- belongs to the DNA/RNA non-specific endonuclease family
- active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules (putative)
Compartment: mitochondria
General
endodeoxyribonuclease
endoribonuclease
mitochondrial protein
oligomerizing protein
Properties
CONFIGURATION: dimer
SIZE: MW = 33 kD
entity length = 297 aa
COMPARTMENT: mitochondria
MOTIF: histidine residue {H141}
Database Correlations
OMIM 600440
UniProt Q14249
Pfam PF01223
Entrez Gene 2021
KEGG correlations
References
UniProt :accession Q14249