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CD105 or endoglin
Function:
- regulatory component of TGF-beta receptor complex
- mediates cellular response to TGF-beta 1
Expression:
- activated monocytes
- endothelial cells
- erythroid precursors in marrow
- syncytiotrophoblasts, cytotrophoblasts in first trimester (transient)
Pathology:
- mutations associated with: hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu syndrome)
Laboratory:
- ENG gene mutation
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
Properties
COMPARTMENT: plasma membrane
MOTIF: glycosylation site
membrane region
Database Correlations
OMIM 131195
UniProt P17813
Entrez Gene 2022
References
- Uniprot P17813
- http://www.pathologyoutlines.com/cd100247.html
21 June 2005