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endocrine myopathy
Etiology:
Thyroid:
1) hyperthyroidism
a) proximal, limb-girdle weakness
b) bulbar paralysis
c) ophthalmoplegia (sparing pupillary & ciliary muscles)
d) thyrotoxic periodic paralysis in Orientals
2) hypothyroidism
a) does not produce significant muscle weakness
b) may cause muscle fatigue, aching & cramps
c) serum creatine kinase is markedly elevated
d) responds to thyroid hormone replacement with rapid & complete resolution of symptoms in most patients
Adrenal
1) hypoadrenalism
2) hypercorticism
Hyperparathyroidism
1) primary or secondary hyperparathyroidism
2) muscle weakness
Acromegaly
1) muscle weakness
2) segmental muscle fiber necrosis
Osteomalacia:
1) proximal muscle weakness
2) non-specific bone pain
3) fatigue
General
metabolic myopathy
endocrine disease
References
- Harrison's Principles of Internal Medicine, 10th edition
Petersdor, Adams, Braunwald et al eds, McGraw Hill, NY, 1983,
pg 2187
- Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998