Eenamelin (ENAM)

Function: - role in the mineralization & structural organization of enamel - role in extension of enamel during the secretory stage of dental enamel formation Compartment: - secreted, extracellular space, extracellular matrix Expression: - expressed in tooth particularly in odontoblast, ameloblast & cementoblast Pathology: - defects in ENAM are the cause of a) amelogenesis imperfecta hypoplastic type 1B b) amelogenesis imperfecta type 1C

General

glycoprotein phosphoprotein secreted protein

Properties

SIZE: entity length = 1142 aa MW = 129 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-39} N-glycosylation site {N114} N-glycosylation site {N126} N-glycosylation site {N245} N-glycosylation site {N252} N-glycosylation site {N265} N-glycosylation site {N296} N-glycosylation site {N467} N-glycosylation site {N534} Thr phosphorylation site {T906} Thr phosphorylation site {T911} N-glycosylation site {N934} N-glycosylation site {N1040}

Database Correlations

OMIM correlations MORBIDMAP 606585 UniProt Q9NRM1 Entrez Gene 10117 Kegg hsa:10117

References

UniProt :accession Q9NRM1