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emelin-2; elastin microfibril interface-located protein 2; elastin microfibril interfacer 2; protein FOAP-10 (EMILIN2)
Function:
1) anchoring smooth muscle cells to elastic fibers
2) regulation of vessel assembly
3) cell adhesive capacity
4) interacts with EMILIN1
Structure:
- homotrimer associated through a moderately stable interaction of the C-terminal globular C1q domains, allowing nucleation of the triple helix & then a further quaternary assembly to higher-order polymers via intermolecular disulfide bonds
- contains 1 C1q domain
- contains 1 collagen-like domain
- contains 1 EMI domain
Compartment:
- secreted, extracellular matrix
- interface between amorphous elastin & microfibrils
Expression:
- expressed in fetal heart, adult lung > peripheral leukocytes, placenta, spinal cord > fetal brain, spleen, thymus lung; adult heart, aorta, testis, bone marrow, small intestine, thymus, lymph node, appendix
General
emilin; elastin microfibril interface located protein
phosphoprotein
Properties
SIZE: entity length = 1053 aa
MW = 116 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-30}
EMI {44-120}
MOTIF: cysteine residue {C48}
MODIFICATION: cysteine residue {C110}
N-glycosylation site {N55}
cysteine residue {C74}
MODIFICATION: cysteine residue {C81}
cysteine residue {C81}
MODIFICATION: cysteine residue {C74}
cysteine residue {C109}
MODIFICATION: cysteine residue {C118}
cysteine residue {C110}
MODIFICATION: cysteine residue {C48}
cysteine residue {C118}
MODIFICATION: cysteine residue {C109}
Ser phosphorylation site {S152}
coiled coil {177-215}
coiled coil {253-340}
MOTIF: N-glycosylation site {N275}
coiled coil {369-389}
N-glycosylation site {N458}
N-glycosylation site {N510}
coiled coil {578-634}
MOTIF: N-glycosylation site {N587}
N-glycosylation site {N616}
N-glycosylation site {N745}
proline-rich region
SITE: 784-839
MOTIF: proline residue (SEVERAL)
Collagen-like {840-892}
proline-rich region
SITE: 893-901
MOTIF: proline residue (SEVERAL)
C1q {901-1053}
MOTIF: N-glycosylation site {N974}
Database Correlations
OMIM 608928
UniProt Q9BXX0
PFAM correlations
Entrez Gene 84034
Kegg hsa:84034
References
UniProt :accession Q9BXX0