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embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; ES cell-specific 5hmC-binding protein; peptidase SRAPD1; SRAP domain-containing protein 1 (HMCES, C3orf37, DC12, SRAPD1)

Function: - specifically binds 5-hydroxymethylcytosine (5hmC)-containing DNA in stem cells, suggesting that it acts as a specific reader of 5hmC in stem cells (putative) - may act as a peptidase [2] Structure: - belongs to the SOS response-associated peptidase family

General

DNA-binding protein peptidase; peptide hydrolase

Properties

SIZE: entity length = 354 aa MW = 41 kD COMPARTMENT: cell nucleus MOTIF: active site DNA-binding motif

Database Correlations

UniProt Q96FZ2 Pfam PF02586 Entrez Gene 56941 Kegg hsa:56941

References

  1. UniProt :accession Q96FZ2
  2. Aravind L, Anand S, Iyer LM. Novel autoproteolytic and DNA-damage sensing components in the bacterial SOS response and oxidized methylcytosine-induced eukaryotic DNA demethylation systems. Biol Direct. 2013 Aug 15;8(1):20 PMID: 23945014