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emapalumab; emapalumab lzsg (Gamifant)

Indications: - primary hemophagocytic lymphohistiocytosis Contraindications: - coadministration of live virus vaccine Dosage: - 1 mg/kg IV infusion over 1 hour twice per week - administer dexamethasone concomitantly - 5 mg/mL; 2 mL, 10 mL Monitor: - test for latent tuberculosis - administer prophylactic treatment against Herpes zoster, Pneumocystis jirovecii Mechanism of action: - inhibits IFN-gamma

Interactions

drug adverse effects of pharmaceutical monoclonal antibodies

General

pharmaceutical monoclonal antibody

References

  1. RxNorm
  2. HIGHLIGHTS OF PRESCRIBING INFORMATION GAMIFANT. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/761107lbl.pdf