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elongin BC complex
Function:
- adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex (VCB complex)
- by binding to BC-box motifs it seems to link target recruitment subunits, like VHL & members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes
Structure:
- consists of at least TCEB1, TCEB2
Related
elongin (SIII, transcription elongation factor B, TEFB)
General
molecular complex
Properties
SUBUNITS: elongin C
COMPARTMENT: cell nucleus
elongin B
COMPARTMENT: cell nucleus
MOTIF: Ubiquitin-like {1-66}
acetylation site
SITE: N-TERMINUS
EFFECTOR-BOUND: acetyl
References
UniProt :accession Q9BZF9
Component-of
ECS complex; elonginB/C-CUL2/5-SOCS-box protein complex; ECS E3 ubiquitin-protein ligase complex
Components
elongin B; elongin 18 kD subunit; transcription elongation factor B polypeptide 2; RNA polymerase II transcription factor SIII subunit B; SIII p18TCEB2 (EloB, TCEB2)
elongin C; elongin 15 kD subunit; transcription elongation factor B polypeptide 1; RNA polymerase II transcription factor SIII subunit C; SIII p15TCEB1 (EloC, TCEB1)