ELL-associated factor 2; testosterone-regulated apoptosis inducer & tumor suppressor protein (EAF2, TRAITS, BM-040)

Function: 1) transcriptional transactivator of TCEA elongation activity (putative) 2) transcriptional transactivator of ELL & ELL2 elongation activities 3) induces apoptosis in prostatic & non-prostatic cell lines 4) inhibits prostate tumor growth in vivo. 5) interacts with ELL, ELL2, TCEA1 Structure: belongs to the EAF family Compartment: - nucleus; nucleoplasm, nuclear speckle - colocalizes with ELL to nuclear speckles Alternative splicing: named isoforms=2 Expression: - expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine, colon, adrenal, bone marrow, lymphe node, spinal gland, stomach, thyroid, trachea, thymus, liver, leukocytes - induction by androgen

General

nuclear protein phosphoprotein

Properties

SIZE: entity length = 260 aa MW = 29 kD COMPARTMENT: cell nucleus MOTIF: ELL interaction {17-104} glutamine-rich region {126-130} MOTIF: glutamine residue (SEVERAL) Ser phosphorylation site {S146} Ser phosphorylation site {S151} Ser phosphorylation site {S154} serine-rich region {174-207} MOTIF: serine residue (SEVERAL) transactivation {177-260} MOTIF: domain {246-260}

Database Correlations

OMIM 607659 UniProt Q96CJ1 Pfam PF09816 Entrez Gene 55840 Kegg hsa:55840

References

UniProt :accession Q96CJ1