ELL-associated factor 1 (EAF1)

Function: 1) transcriptional transactivator of ELL & ELL2 elongation activities 2) interacts with ELL & ELL2 Structure: - belongs to the EAF family Compartment: - nucleus, nuclear speckle, Cajal body - colocalizes with ELL to nuclear speckles Expression: - expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, prostate, testis, small intestine & colon > thymus

General

phosphoprotein transcription factor (TF)

Properties

SIZE: MW = 29 kD entity length = 268 aa COMPARTMENT: cell nucleus MOTIF: proline-rich region SITE: 127-168 MOTIF: proline residue (SEVERAL) Ser phosphorylation site {S158} Ser phosphorylation site {S165} transactivation {182-262} MOTIF: serine-rich region {188-211} MOTIF: serine residue (SEVERAL)

Database Correlations

OMIM 608315 UniProt Q96JC9

References

UniProt :accession Q96JC9